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Provided are methods of diagnosing IgA nephropathy in a subject. Optionally, the methods comprise isolating an IgG from the subject and determining whether the IgG binds to a galactose-deficient IgA1. Optionally, the methods comprise providing a biological sample from the subject and detecting in the sample a mutation in a IGH gene, wherein the mutation is in a nucleotide sequence encoding a complementarity determining region 3 (CDR3) of a IGH variable region. Optionally, the methods comprise determining a level of IgG specific for a galactose-deficient IgA1 in the subject. Also provided are methods of treating or reducing the risk of developing IgA nephropathy in a subject.

Docket:WRAMC 10-26

Publication/Issued No.:9,655,963

Publication/Issue Date:2017-05-23

Categories: Assay

More Detail:Visit USPTO.GOVExternal link


Inventor(s):HITOSHI, ET AL

For Licensing Opportunities, please contact the ORTA at

Last Modified Date: 25 Jul 2023

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