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COMBINATIONS OF GENE DELETIONS FOR LIVE ATTENUATED SHIGELLA VACCINE STRAINS
Shigella vaccine strains whose primary attenuating feature is deletion of the virG(icsA) gene and additional two or more deletions in setAB(shET1), senA(shET2), senB(shET2-2), stxAB, and msbB2 genes. Thus, the vaccine strain will have three or more deletions in the identified genes, will be safer, and will reduce or eliminate symptoms of fever and diarrhea in humans. The following specific vaccine strains have been constructed: WRSS3 (.DELTA.senA, .DELTA.senB, .DELTA.virG, .DELTA.msbB2), WRSf2G15 (.DELTA.virG, .DELTA.setAB, .DELTA.senA, .DELTA.senB, .DELTA.msbB2), and WRSd5 (.DELTA.virG, .DELTA.stxAB, .DELTA.senA, .DELTA.senB, .DELTA.msbB2).
Docket:WRAIR 06-76
Publication/Issued No.:8,986,708
Publication/Issue Date:2015-03-24
Categories: Method,Vaccine
More Detail:Visit USPTO.GOV
Lab:WRAIR
Inventor(s):VENKATASEN, ET AL