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Technologies Available for Licensing

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COMPOSITIONS CONTAINING FULL-LENGTH L1R NUCLEIC ACID AND ENDOPLASMIC RETICULUM TARGETING SEQUENCE, AND METHODS OF USE

The invention described here encompasses DNA and protein vaccines against poxviruses, and relevant immunogenic compositions, comprising at a minimum a nucleic acid encoding a modified full-length poxvirus L1R gene or its ortholog. The L1R gene is modified so that an endoplasmic reticulum-targeting sequence is operably linked on the 5' end. Preferably the nucleic acid sequences for other poxviruses antigens are also included, such as A33R, B5R and/or A27L. These vaccines and compositions provide improved neutralizing antibody response elicited by molecular poxvirus vaccines, over known vaccines using unmodified L1R.


Docket:RIID 2007-36

Publication/Issued No.:8,513,005

Publication/Issue Date:2013-08-20

Categories: Vaccine

More Detail:Visit USPTO.GOVExternal link

Lab:RIID

Inventor(s):HOOPER, ET AL

For Licensing Opportunities, please contact the ORTA at USArmy.Detrick.MEDCOM-USAMRMC.List.ORTA@health.mil
 
 

Last Modified Date: 25 Jul 2023

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