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The invention contemplates a new synthetic, codon-optimized Puumala virus (PUUV) full-length M gene open reading frame (ORF) that encodes a unique consensus amino acid sequence. The PUUV ORF was cloned into a plasmid to form the first stable PUUV full-length M gene that elicits neutralizing antibodies. The gene can be engineered into a molecular vaccine system, and is useful to protect mammals against infection with Puumala virus.

Docket:RIID 07-09

Publication/Issued No.:8,183,358

Publication/Issue Date:2012-05-22

Categories: Vaccine

More Detail:Visit USPTO.GOVExternal link


Inventor(s):HOOPER, J.; SCHMALJOHN, C.

For Licensing Opportunities, please contact the ORTA at

Last Modified Date: 25 Jul 2023

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