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2-GUANIDINYLIMIDAZOLIDINEDIONE COMPOUNDS AND METHODS OF MAKING AND USING THEREOF
Disclosed herein are 2-guanidinylimidazolidinedione compounds having the structural formula A or B ##STR00001## wherein R.sup.1 and R.sup.2 are each independently a hydrogen, halogen, alkyl, alkoxyl, amino, alkylamino or aralkyl, and wherein R.sup.3 is an alkyl, cycloalkyl, heterocycloalkyl, acyl, aryl, heteroaryl, alkylaryl, sulfonyl, alkylsulfonyl, and pharmaceutically acceptable salts thereof, and methods of making thereof. Also disclosed are methods of treating, preventing, or inhibiting malaria with the 2-guanidinylimidazolidinedione compounds, and pharmaceutical compositions comprising the 2-guanidinylimidazolidinedione compounds, and kits.
Docket:WRAIR 2003-10
Publication/Issued No.:7,101,902
Publication/Issue Date:2006-09-05
Categories: Vaccine
More Detail:Visit USPTO.GOV
Lab:WRAIR
Inventor(s):LIN, A.; ZHANG, Q.; GUAN, J.; MILHOUS, W.