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PLASMODIUM FALCIPARUM AMA-1 PROTEIN AND USES THEREOF
In this application is described the expression and purification of a recombinant Plasmodium falciparum (3D7) AMA-1 ectodomain. The method of the present invention produces a highly purified protein which retains folding and disulfide bridging of the native molecule. The recombinant AMA-1 is useful as a diagnostic reagent, for use in antibody production, and as a protein for use alone, or as part of, a vaccine to prevent malaria.
Docket:WRAIR 01-33
Publication/Issued No.:7,029,685
Publication/Issue Date:2006-04-18
Categories: Method
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Lab:WRAIR
Inventor(s):LANAR, D.; DUTTA, S.; WARE, L.; NAIR, L.