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VACCINE AGAINST GRAM-NEGATIVE BACTERIAL INFECTIONS
A vaccine, effective in inducing the production of antibodies with which to immunize a second subject passively against infection by Gram-negative bacteria and LPS-mediated pathology, comprises a non-covalent polyvalent complex formed between purified, detoxified LPS derived from E. coli and purified outer membrane protein derived from N. meningitidis. The same vaccine will also actively immunize a host subject against Gram-negative bacterial infections and LPS-mediated pathology. Meningococcal infections are included among those Gram-negative bacterial infections protected against by the vaccine.
Docket:WRAIR 92-17
Publication/Issued No.:7,025,963
Publication/Issue Date:2006-04-11
Categories: Vaccine
More Detail:Visit USPTO.GOV
Lab:WRAIR
Inventor(s):BHATTACHARJEE, A.; CROSS, A.; SADOFF, J.; ZOLLINGER, W.