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Technologies Available for Licensing
ARTEMISININS WITH IMPROVED STABILITY AND BIOAVAILABILITY FOR THERAPEUTIC DRUG DEVELOPMENT AND APPLICATION
A stable form of artemisinin wherein an artelinic acid or artesunic acid is complexed with cyclodextrin analogs, preferably, .beta.-cyclodextrin. The complexed cyclodextrin artemisinin formulation shields the peroxide portion of the artemisinin backbone from hydrolytic decomposition rendering it stable in solution. Artelinic acid and cyclodextrin are placed into contact with one another to yield a 2:1 molecular species. Artesunic acid and cyclodextrin yield a 1:1 molecular species. The complexed cyclodextrin artemisinin formulation is effective for the treatment of malaria and is stable in solution for long periods of time.
Docket:WRAIR 2002-29
Publication/Issued No.:6,951,846
Publication/Issue Date:2005-10-04
Categories: Treatment
More Detail:Visit USPTO.GOV
Lab:WRAIR
Inventor(s):HARTELL, M.; BHATTACHARJEE, A.; HICKS, R.; VAN HAMMONT, J.; MILHOUS, W.