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Technologies Available for Licensing

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ARTEMISININS WITH IMPROVED STABILITY AND BIOAVAILABILITY FOR THERAPEUTIC DRUG DEVELOPMENT AND APPLICATION

A stable form of artemisinin wherein an artelinic acid or artesunic acid is complexed with cyclodextrin analogs, preferably, .beta.-cyclodextrin. The complexed cyclodextrin artemisinin formulation shields the peroxide portion of the artemisinin backbone from hydrolytic decomposition rendering it stable in solution. Artelinic acid and cyclodextrin are placed into contact with one another to yield a 2:1 molecular species. Artesunic acid and cyclodextrin yield a 1:1 molecular species. The complexed cyclodextrin artemisinin formulation is effective for the treatment of malaria and is stable in solution for long periods of time.


Docket:WRAIR 2002-29

Publication/Issued No.:6,951,846

Publication/Issue Date:2005-10-04

Categories: Treatment

More Detail:Visit USPTO.GOVExternal link

Lab:WRAIR

Inventor(s):HARTELL, M.; BHATTACHARJEE, A.; HICKS, R.; VAN HAMMONT, J.; MILHOUS, W.

For Licensing Opportunities, please contact the ORTA at USArmy.Detrick.MEDCOM-USAMRMC.List.ORTA@health.mil
 
 

Last Modified Date: 16 May 2023

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