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USE OF PENETRATION ENHANCERS AND BARRIER DISRUPTION AGENTS TO ENHANCE THE TRANSCUTANEOUS IMMUNE RESPONSE.
A transcutaneous immunization system where the topical application of an adjuvant and an antigen or nucleic acid encoding for an antigen, to intact skin induces a ystemic or mucosol antibody response. The immune response so elicited can be enhanced by physical or chemical skin penetration enhancement.
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Inventor(s):GLENN, G.; ALVING, C.