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The present invention provides a method for replicating virus to high titer in cultured mammalian cells by infecting the mammalian cells with the high titer virus strain to obtain infected cells, specifically, attenuated dengue virus strains of serotype 1, 2, 3, and 4. The resulting replicated virus is suitable for use in vaccines and vaccination methods which are also provided by the invention.

Docket:WRAIR 99-15

Publication/Issued No.:6,613,556

Publication/Issue Date:2003-09-02

Categories: Vaccine

More Detail:Visit USPTO.GOVExternal link


Inventor(s):ECKELS, ET AL

For Licensing Opportunities, please contact the ORTA at

Last Modified Date: 25 Jul 2023

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