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ALPHAVIRUS RNA REPLICON SYSTEMS

The present invention provides a helper cell for expressing an infectious, replication defective, alphavirus particle in an alphavirus-permissive cell. The helper cell includes (a) a first helper RNA encoding (i) at least one alphavirus structural protein, and (ii) not encoding at least one alphavirus structural protein; and (b) a second helper RNA separate from the first helper RNA, the second helper RNA (i) not encoding the alphavirus structural protein encoded by the first helper RNA, and (ii) encoding the at least one alphavirus structural protein not encoded by the first helper RNA. Preferably, the helper cell is co-transfected with a replicon RNA encoding an alphavirus packaging segment and an inserted heterogeneous RNA, such that all of the alphavirus structural proteins assemble together into alphavirus particles in the cell, with said replicon RNA packaged therein.


Docket:RIID 95-32

Publication/Issued No.:6,541,010

Publication/Issue Date:2003-04-01

Categories: Vaccine

More Detail:Visit USPTO.GOVExternal link

Lab:RIID

Inventor(s):JOHNSTON, R.; DAVIS, N.; SMITH, J.; PUSHKO, P.; PARKER, M.; LUDWIG, G.

For Licensing Opportunities, please contact the ORTA at USArmy.Detrick.MEDCOM-USAMRMC.List.ORTA@health.mil
 
 

Last Modified Date: 25 Jul 2023

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