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SHIGELLA VECTOR FOR DELIVERING DNA TO A MAMMALIAN CELL

We describe a bacterial delivery system for the delivery of DNA and antigens into cells. We constructed an attenuated bacterial vector which enters mammalian cells and ruptures delivering functional plasmid DNA, such as a mammalian expression plasmid, and antigens into the cell cytoplasm. This Shigella vector was designed to deliver DNA to colonic surfaces, thus opening the possibility of oral and other mucosal DNA immunization and gene therapy strategies. The attenuated Shigella is also useful as a vaccine for reducing disease symptoms caused by Shigella.


Docket:WRAIR 95-16

Publication/Issued No.:5,824,538

Publication/Issue Date:1998-10-20

Categories: Method

More Detail:Visit USPTO.GOVExternal link

Lab:WRAIR

Inventor(s):BRANSTROM, A.; SIZEMORE, D.; SADOFF, J.

For Licensing Opportunities, please contact the ORTA at USArmy.Detrick.MEDCOM-USAMRMC.List.ORTA@health.mil
 
 

Last Modified Date: 25 Jul 2023

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