An official website of the United States government
) or https:// means you've safely connected to the .mil website. Share sensitive information only on official, secure websites.
Technologies Available for Licensing
SHIGELLA VECTOR FOR DELIVERING DNA TO A MAMMALIAN CELL
We describe a bacterial delivery system for the delivery of DNA and antigens into cells. We constructed an attenuated bacterial vector which enters mammalian cells and ruptures delivering functional plasmid DNA, such as a mammalian expression plasmid, and antigens into the cell cytoplasm. This Shigella vector was designed to deliver DNA to colonic surfaces, thus opening the possibility of oral and other mucosal DNA immunization and gene therapy strategies. The attenuated Shigella is also useful as a vaccine for reducing disease symptoms caused by Shigella.
Docket:WRAIR 95-16
Publication/Issued No.:5,824,538
Publication/Issue Date:1998-10-20
Categories: Method
More Detail:Visit USPTO.GOV
Lab:WRAIR
Inventor(s):BRANSTROM, A.; SIZEMORE, D.; SADOFF, J.