Technologies Available for Licensing
POINT-OF-CARE IN-VITRO DIAGNOSTIC DEVICE FOR THE AMPEROMETRIC DETECTION OF CHOLINESTERASE ACTIVITY IN WHOLE BLOOD FOR INDICATION OF EXPOSURE TO CHOLINESTERASE INHIBITING SUBSTANCES
A system that can assess red blood cell AChE activity to provide warning of exposure and possibly inform treatment with medical countermeasures is disclosed. A portable, ideally hand-held, in vitro diagnostic point of care system capable of electrochemically-based detection of red blood cell acetylcholinesterase (AChE) activity from an undiluted whole blood sample provides a real-time pre-symptomatic warning of exposure to organophosphorus nerve agent or other poison, such as a pesticide, which informs treatment with medical countermeasures. One preferred version of the invention provides a system that uses highly stable test strips and a lightweight, low power hand-held potentiostat detector. The disclosed invention provides a real-time quantitative assessment of cholinesterase (ChE) enzymatic activity directly from a small whole blood sample for indication of exposure to ChE inhibiting substances (i.e., chemical warfare nerve agents or carbamate pesticides), thereby allowing immediate assessment of a blood sample in the field during the pre-symptomatic window.
Docket:RICD 17-33-US02
Publication/Issued No.:10,913,967
Publication/Issue Date:2021-02-09
Categories: Diagnostic
More Detail:Visit USPTO.GOV
Lab:RICD
Inventor(s):KASTEN, S.